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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C2 All Species: 36.36
Human Site: S561 Identified Species: 66.67
UniProt: Q9UKV8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKV8 NP_001158095.1 859 97208 S561 R T T P Q T L S N L C L K I N
Chimpanzee Pan troglodytes XP_001142838 813 92351 L532 L G G V N N I L L P Q G R P P
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 S755 R T T P Q T L S N L C L K I N
Dog Lupus familis XP_532338 899 101246 S601 R T T P Q T L S N L C L K I N
Cat Felis silvestris
Mouse Mus musculus Q8CJG0 860 97305 S562 R T T P Q T L S N L C L K I N
Rat Rattus norvegicus Q9QZ81 860 97300 S562 R T T P Q T L S N L C L K I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513588 873 98974 S575 R T T P Q T L S N L C L K I N
Chicken Gallus gallus Q5ZLG4 860 97253 S562 K T S P Q T L S N L C L K I N
Frog Xenopus laevis Q6DCX2 862 97626 S564 R T T P Q T L S N L C L K I N
Zebra Danio Brachydanio rerio A3KPK0 860 97313 S562 K T S P Q T L S N L C L K I N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 L934 Q T I G N I L L K I N S K L N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 A705 R P T P A T C A N I V L K L N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 A721 K M S K Q Y M A N V A L K I N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.6 80.2 95.3 N.A. 98.9 99 N.A. 97.1 79.7 96.1 79.4 N.A. 22.4 N.A. 33.4 N.A.
Protein Similarity: 100 94.6 81 95.3 N.A. 99 99.3 N.A. 97.5 89.3 98.2 89.4 N.A. 36.4 N.A. 51.5 N.A.
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. 100 86.6 100 86.6 N.A. 26.6 N.A. 53.3 N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 46.6 N.A. 73.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 37.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 53.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 40 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 16 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 70 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 8 0 0 0 0 0 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 8 8 0 0 16 0 0 0 77 0 % I
% Lys: 24 0 0 8 0 0 0 0 8 0 0 0 93 0 0 % K
% Leu: 8 0 0 0 0 0 77 16 8 70 0 85 0 16 0 % L
% Met: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 16 8 0 0 85 0 8 0 0 0 93 % N
% Pro: 0 8 0 77 0 0 0 0 0 8 0 0 0 8 8 % P
% Gln: 8 0 0 0 77 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 62 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % R
% Ser: 0 0 24 0 0 0 0 70 0 0 0 8 0 0 0 % S
% Thr: 0 77 62 0 0 77 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 8 0 0 0 0 0 8 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _